Comprehensive Phenotyping of Immune Cell Subsets
The development of immuno-modulating therapies requires a comprehensive monitoring of patients' immune cell subsets in order to characterize the impact of the drugs on the immune system.
IMMUNE CELL MONITORING INCLUDES
• Measuring the frequency and absolute number of specific immune cell subsets in biological fluids (i.e. peripheral blood, CSF, etc.) and tissues.
• Monitoring changes in the expression of specific intra-cellular or cell-surface markers by immune cells.
• Enumerating antigen specific humoral and cellular immune responses (antibody secreting B cells, CD4 and/or CD8 T cells, etc.).
• Analyzing changes in the functional properties of different cell subsets : cytotoxicity, proliferation, secretion patterns of soluble biomarkers', regulatory/suppressive functions, migratory potential, etc.
Immune monitoring can also help determine the mechanism of action of an investigational drug, by revealing potential prognostic/predictive surrogate markers of clinical response, of immune related
adverse events (lrAEs) or of secondary resistance that can occur in clinical trial participants treated with Immune check point inhibitors, CART cells or therapeutic vaccines.
Active Biomarkers provides its partners with expert solutions through comprehensive design and adaptation of phenotypic and functional assays for characterization of immune cell subsets. Custom analytical methods are
optimized and qualified prior to routine sample testing and are guided by Active Biomarkers' decades of experience in cell culture, flow cytometry and ELISpot.
For more information on our immune monitoring services, please contact us at : info@active-biomarkers.com.